RAF Typhoon FGR4s have conducted a mission with French warplanes in a joint strike against an subterranean weapons facility in Syrian territory used by the IS group, according to the UK's MoD.
The facility, pinpointed through intelligence, was assessed as storing arms and explosives, the statement said, and was positioned in hills just above the historic site of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to hit a number of approach shafts leading to the facility... initial indications indicate the strike was effective," the ministry announced.
There was no indication of any harm to civilians in the attack on Saturday evening and all the aircraft returned to base without incident, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager tanker plane.
Daesh - also known as ISIS - established jihadist rule over parts of Syria and Iraq before its territorial defeat in 2019.
"This strike shows our UK leadership, and resolve to work closely with our allies, to eradicate any resurgence of IS and their violent and radical beliefs in the area," the British Defence Secretary the minister said.
RAF aircraft have carried out overwatch operations over Syria to "deter any efforts to regroup" of Islamic State following its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to every member of our armed forces involved in this mission for their expertise and their valour," the Defence Secretary added. "Including them were numerous British troops on duty over the festive period. This action, to eliminate dangerous terrorists who endanger our way of life, highlights how our armed forces are prepared to act, continuously, protecting the UK within its borders and powerful internationally."
During December, the United States armed forces conducted what it described as a "large-scale strike" on Daesh sites in the country, subsequent to an ambush resulted in the deaths of two US servicemembers and a civilian interpreter in the Palmyra area.
The UN estimates IS still maintains roughly 5-7 thousand combatants in both countries.